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Article

The multifunctional role of filaggrin in allergic skin disease.

The Journal of allergy and clinical immunology - 1 Feb 2013

McAleer Maeve A, Irvine Alan D

Abstract excerpt

Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in the filaggrin gene are the most significant known genetic risk factor for the development of atopic dermatitis. Mutations in the human filaggrin gene (FLG) also confer risk for the associated allergic diseases of food allergy, asthma, and allergic rhinitis. These discoveries have highlighted the importance of skin...

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Source

Identifiers

PMID: 23374260
DOI: 10.1016/j.jaci.2012.12.668

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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