Article

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

2019-11-26

Abstract excerpt

<h4>Background: </h4> Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( FLG ) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Skin as an organ that can be modelled using primary cells in vitro provides the opportunity f...

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Literature Corpus work: 17f43fde-1b10-5243-bdf8-c5308fd8c8c1
DOI: 10.12688/wellcomeopenres.15405.2

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