Article

Metabolic fate of human immunoactive sterols in <i>Mycobacterium tuberculosis</i>

2020-07-07

Abstract excerpt

Mycobacterium tuberculosis (Mtb) infection is among top ten causes of death worldwide, and the number of drug-resistant strains is increasing. The direct interception of human immune signaling molecules by Mtb remains elusive, limiting drug discovery. Oxysterols and secosteroids regulate both innate and adaptive immune responses. Here we report a functional, structural, and bioinformatics study of Mtb enzymes init...

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Literature Corpus work: de7d9cc0-9b4b-596a-a762-62ec2108bcfe
DOI: 10.1101/2020.07.07.192294

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