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Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus

23 Mar 2012

Abstract excerpt

There is a well documented need to replenish the antibiotic pipeline with new agents to combat the rise of drug resistant bacteria. One strategy to combat resistance is to discover new chemical classes immune to current resistance mechanisms that inhibit essential metabolic enzymes. Many of the obvious drug targets that have no homologous isozyme in the human host have now been investigated. Bacterial drug...

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PMID: 22437830
DOI: 10.1074/jbc.m112.356576

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