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Article

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens.

Nature microbiology - 1 Jan 2020

Carfrae Lindsey A, MacNair Craig R, Brown Christopher M, Tsai Caressa N, Weber Brent S, Zlitni Soumaya, Rao Vishwas N, Chun Joshua, Junop Murray S, Coombes Brian K, Brown Eric D

Abstract excerpt

To revitalize the antibiotic pipeline, it is critical to identify and validate new antimicrobial targets1. In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fitness determinant during infection2-5, making it a high-priority target. However, biotin biosynthesis has been overlooked for priority pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas...

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PMID: 31659298
DOI: 10.1038/s41564-019-0595-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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