Article

Genetic Dependency of Alzheimer’s Disease-Associated Genes across Cells and Tissue Types

2021-02-02

Abstract excerpt

Effective treatments targeting disease etiology are urgently needed for Alzheimer’s disease (AD). Although candidate AD genes have been identified and altering their levels may serve as therapeutic strategies, the consequence of such alterations remain largely unknown. Herein, we analyzed CRISPR knockout/RNAi knockdown screen data for over 700 cell lines and evaluated cellular dependencies of 104 AD-associated gen...

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Literature Corpus work: 57663273-07db-5b22-993e-f89df99243a0
DOI: 10.21203/rs.3.rs-153131/v1

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