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Article

Genetic dependency of Alzheimer's disease-associated genes across cells and tissue types.

Scientific reports - 8 Jun 2021

Jaladanki Suraj K, Elmas Abdulkadir, Malave Gabriel Santos, Huang Kuan-Lin

Abstract excerpt

Effective treatments targeting disease etiology are urgently needed for Alzheimer's disease (AD). Although candidate AD genes have been identified and altering their levels may serve as therapeutic strategies, the consequence of such alterations remain largely unknown. Herein, we analyzed CRISPR knockout/RNAi knockdown screen data for over 700 cell lines and evaluated cellular dependencies of 104 AD-associated...

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Identifiers

PMID: 34103633
DOI: 10.1038/s41598-021-91713-2
PMCID: PMC8187448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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