Intrinsically disordered regions in the NLRP family of receptors act as regulatory hubs for inflammasome condensation and activation.

Abstract excerpt

Inflammasomes are multiprotein complexes that orchestrate immune responses to pathogenic and sterile insults by regulating the maturation of inflammatory cytokines and pyroptotic cell death. While inflammasome activation is well-characterized at the biochemical level, the mechanisms governing the spatial and temporal assembly of these complexes remain poorly understood. Here, we uncover a critical role for...

Topics

• Inflammasomes
• Humans
• NLR Family, Pyrin Domain-Containing 3 Protein
• NLR Proteins
• Protein Processing, Post-Translational