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Article

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.

Current opinion in immunology - 1 Feb 2013

Haneklaus Moritz, O'Neill Luke A J, Coll Rebecca C

Abstract excerpt

The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with...

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Topics

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Share to Calcium Signaling
Share to Cryopyrin-Associated Periodic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunomodulation

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

Identifiers

PMID: 23305783
DOI: 10.1016/j.coi.2012.12.004

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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