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Article

Somatic mutational profiles and germline polygenic risk scores in human cancer.

Genome medicine - 11 Feb 2022

Liu Yuxi, Gusev Alexander, Heng Yujing J, Alexandrov Ludmil B, Kraft Peter

Abstract excerpt

BACKGROUND: The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-base substitution (SBS) signatures, may reflect the effects of exogenous or endogenous exposures. METHODS: We used...

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Identifiers

PMID: 35144655
DOI: 10.1186/s13073-022-01016-y
PMCID: PMC8832866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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