Article

Somatic mutational profiles and germline polygenic risk scores in human cancer

2021-01-30

Abstract excerpt

<h4>ABSTRACT</h4> The mutational profile of a cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational signatures. Mutational signatures, including single-based substitution (SBS) signatures, may reflect the effects of exogenous or endogenous exposures. Here, we...

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Literature Corpus work: 46632768-5f4c-5d87-a547-ed5ddc41a37a
DOI: 10.1101/2021.01.28.428663

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