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Article

Association between polygenic risk and survival in breast cancer patients.

BMC cancer - 28 Aug 2025

Kurant Danielle E, Groha Stefan, Ding Yi, German Chris, Wang Wei, Granka Julie M, Holmes Michael V, Shringarpure Suyash S, Gusev Alexander Sasha

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) estimate an individual’s germline genetic predisposition to a quantitative trait and/or risk of disease. Several PRS have been developed for cancer risk with the goal of improved risk screening. Here, we sought to establish whether PRS for cancer risk and other common traits may influence survival for patients with cancer. METHODS: We conducted a PRS survival analysis using...

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Identifiers

PMID: 40877800
DOI: 10.1186/s12885-025-14640-9
PMCID: PMC12392544

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