Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative.

doi:10.1016/j.ajhg.2018.04.001

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Article

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative.

American journal of human genetics - 7 Jun 2018

Fritsche Lars G, Gruber Stephen B, Wu Zhenke, Schmidt Ellen M, Zawistowski Matthew, Moser Stephanie E, Blanc Victoria M, Brummett Chad M, Kheterpal Sachin, Abecasis Gonçalo R, Mukherjee Bhramar

Abstract excerpt

Health systems are stewards of patient electronic health record (EHR) data with extraordinarily rich depth and breadth, reflecting thousands of diagnoses and exposures. Measures of genomic variation integrated with EHRs offer a potential strategy to accurately stratify patients for risk profiling and discover new relationships between diagnoses and genomes. The objective of this study was to evaluate whether...

Topics

Calibration
Female
Genetic Association Studies
Genome-Wide Association Study
Genomics
Humans
Male
Middle Aged
Multifactorial Inheritance
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Reproducibility of Results

Risk Factors

Time Factors

Source

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Identifiers

PMID: 29779563
DOI: 10.1016/j.ajhg.2018.04.001
PMCID: PMC5992124

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