Article

Lymphoid Enhancer-Binding Factor 1 (LEF1) immunostaining as a surrogate of β-catenin (<i>CTNNB1)</i>mutations

2022-04-02

Abstract excerpt

<h4>Background</h4> Activating mutations affecting exon 3 of the β-catenin ( CTNNB1 ) gene result in constitutive activation of WNT signaling and are a diagnostic hallmark of several tumor entities including desmoid-type fibromatosis. They also define clinically relevant tumor subtypes within certain entities such as endometrioid carcinoma. In diagnostics, β-catenin immunohistochemistry is widely used as a surroga...

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Literature Corpus work: 5717ece9-b755-5265-a40b-84c32448b926
DOI: 10.1101/2022.03.30.22273113

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