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Article

Activation of β-Catenin Signaling and its Crosstalk With Estrogen and Histone Deacetylases in Human Uterine Fibroids

25 Nov 2019

Abstract excerpt

CONTEXT: Uterine fibroids (UF) are the most common benign tumor of the myometrium (MM) in women of reproductive age. However, the mechanism underlying the pathogenesis of UF is largely unknown. OBJECTIVE: To explore the link between nuclear β-catenin and UF phenotype and β-catenin crosstalk with estrogen and histone deacetylases (HDACs). DESIGN: Protein/RNA levels of β-catenin (CTNNB1 gene), its responsive...

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PMID: 31761932
DOI: 10.1210/clinem/dgz227

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