CTNNB1 Mutational analysis enhances diagnostic precision in β-catenin-negative desmoid fibromatosis: a clinicopathological and molecular study.

doi:10.1007/s00428-026-04405-5

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Article

CTNNB1 Mutational analysis enhances diagnostic precision in β-catenin-negative desmoid fibromatosis: a clinicopathological and molecular study.

Virchows Archiv : an international journal of pathology - 1 Mar 2026

Wang Yang, Wang Ying, Sun Lin, Zheng Ruizhi, Liu Ming, Zhang Yanhui, Guo Yuhong, Zhao Gang, Sun Yan

Abstract excerpt

Diagnostic challenges remain in desmoid fibromatosis (DF) due to somewhat frequent β-catenin immunohistochemical negativity, risking misclassification and overtreatment. The present study evaluates the role of CTNNB1 molecular testing in optimizing diagnosis. A single-center, large retrospective analysis of 780 patients with DF was performed. The incidence of DF was higher in females, particularly within the...

Topics

Humans
beta Catenin
Female
Desmoid Tumors
Adult
DNA Mutational Analysis
Middle Aged
Male
Mutation
Adolescent
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Young Adult

Child

Aged

Child, Preschool

Biomarkers, Tumor

Immunohistochemistry

Infant

Source

Open in PubMed

Identifiers

PMID: 41586907
DOI: 10.1007/s00428-026-04405-5

Genes

CTNNB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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