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Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation

29 Jan 2025

Abstract excerpt

OBJECTIVE: This study aimed to compare the expression of lymphoid enhancer factor 1 (LEF1) and β-catenin in basal cell adenoma (BA), desmoid-type fibromatosis (DF), and pancreatic solid pseudopapillary neoplasm (SPN) to evaluate their diagnostic utility in tumors associated with the WNT/β-catenin signaling pathway harboring the mutation of CTNNB1 gene 3 exon. METHODS: Eighty tumor patients, including 26 BAs, 30...

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PMID: 39881334
DOI: 10.1186/s12957-025-03675-8

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