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Article

CTNNB1 mutation represents a recurrent driver molecular alteration in a subset of endometrial stromal tumors.

Virchows Archiv : an international journal of pathology - 1 Mar 2026

Dundr Pavel, Radová Eliška, Hojný Jan, Kudrnová Nikola, Kendall Bártů Michaela, Němejcová Kristýna, Kalousová Marta, Frühauf Filip, Cibula David, Matěj Radoslav, McCluggage W Glenn, Stružinská Ivana

Abstract excerpt

Low-grade endometrial stromal sarcomas (LGESS) and endometrial stromal nodules represent a distinct entity with characteristic morphology, immunohistochemical profile, and molecular features. It has been suggested that the activation of the Wnt signaling pathway is a potential driver in some of these tumors. Approximately 70-75% of LGESS are characterized by non-random recurrent fusions mostly involving JAZF1 and...

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Source

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Identifiers

PMID: 41606383
DOI: 10.1007/s00428-026-04420-6
PMCID: PMC12963160

Genes

CTNNB1
GREB1
JAZF1
PHF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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