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Article

Clinicopathological and genomic characterization of BCORL1-driven high-grade endometrial stromal sarcomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2021

Lin Douglas I, Huang Richard S P, Mata Douglas A, Decker Brennan, Danziger Natalie, Lechpammer Mirna, Hiemenz Matthew, Ramkissoon Shakti H, Ross Jeffrey S, Elvin Julia A

Abstract excerpt

BCORL1 is a transcriptional corepressor homologous to BCOR. We describe 12 BCORL1-altered uterine sarcomas with striking resemblance to BCOR-altered endometrial stromal sarcoma (BCOR-ESS), including 5 with BCORL1 rearrangements (JAZF1-BCORL1, EP300-BCORL1, or internal BCORL1 rearrangement), 5 with inactivating BCORL1 mutations (T513fs*22, P600fs*1, R945*, R1196*, or R1265fs*4) and 2 with homozygous BCORL1...

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PMID: 34302054
DOI: 10.1038/s41379-021-00873-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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