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Article

Differential Localization of β-Catenin Protein in CTNNB1 Mutant Endometrial Cancers Results in Distinct Transcriptional Profiles.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2025

Parrish Molly L, Osborne-Frazier Macy L, Broaddus Russell R, Gladden Andrew B

Abstract excerpt

CTNNB1 exon 3 mutation is a well-established driver of nearly 30% of endometrioid endometrial cancers (EECs), and this is associated with worse patient survival. Paradoxically, we have previously demonstrated that mutant β-catenin protein does not robustly localize to the nucleus in these cancers. The purpose of this study was to determine downstream gene expression in these cancers with nuclear or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40348058
DOI: 10.1016/j.modpat.2025.100791
PMCID: PMC12353630

Genes

CTNNB1
TACSTD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Differential Localization of β-Catenin Protein in CTNNB1 Mutant Endometrial Cancers Results in Distinct Transcriptional Profiles.PMID 40348058Read ↗

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