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Clinicopathologic and Immunohistochemical Correlates of CTNNB1 Mutated Endometrial Endometrioid Carcinoma

7 Feb 2019

Abstract excerpt

Endometrial endometrioid carcinomas (EECs) with exon 3 CTNNB1 mutations characterize a more aggressive subset of tumors in patients with low-grade low-stage disease. Thus, prospectively identifying these cases may be clinically relevant. The aim of this study was to examine the feasibility of β-catenin and Cyclin D1 immunohistochemistry to identify EECs harboring CTNNB1 mutations and to evaluate the...

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Share to Cancer-related gene regulation
Share to Endometrial and Cervical Cancer Treatments
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 30702464
DOI: 10.1097/pgp.0000000000000583

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