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Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in <i>Escherichia coli</i>

2026-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic heteroresistance, the presence of a rare resistant subpopulation within an otherwise susceptible bacterial population, poses a significant clinical challenge. Understanding its genetic mechanisms is critical for early detection and treatment efficacy. Here, we investigate the contribution of small plasmids to heteroresistance using a clinical bloodstream Escherichia coli isolate carr...

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Literature Corpus work
95f6ba95-e89c-5f86-9038-450ba9c8922c
DOI
10.64898/2026.08.19.745753
Open publication

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Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in <i>Escherichia coli</i>DOI 10.64898/2026.08.19.745753
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