Article

Cost and benefits of gene amplification-mediated antibiotic resistance

2026-03-19

Abstract excerpt

Bacteria evolve antibiotic resistance through various mechanisms, including horizontal gene transfer, sequence-altering mutations, and tandem duplications/amplifications in genomic regions that increase the dosage of resistance determinants. This phenomenon, known as gene duplication-amplification (GDA), is a transient and reversible genetic mechanism that allows bacteria to rapidly adapt to antibiotic stress. Due...

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Literature Corpus work: 4d1da6e8-b380-53a3-b488-d7fd6aa77784
DOI: 10.64898/2026.03.19.712897

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