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Rates of resistance and heteroresistance to newer β-lactam/β-lactamase inhibitors for carbapenem-resistant Enterobacterales

5 Mar 2024

Abstract excerpt

Abstract Background Heteroresistance (HR), the presence of antibiotic-resistant subpopulations within a primary isogenic population, may be a potentially overlooked contributor to newer β-lactam/β-lactamase inhibitor (BL/BLI) treatment failure in carbapenem-resistant Enterobacterales (CRE) infections. Objectives To determine rates of susceptibility and HR to BL/BLIs ceftazidime/avibactam, imipenem/relebactam and...

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PMID: 38515868
DOI: 10.1093/jacamr/dlae048

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