Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors.

Abstract excerpt

Diabetes mellitus derives from either insulin deficiency (type I) or resistance (type II). Homozygous mutations in the insulin receptor (IR) gene cause the rare leprechaunism and Rabson-Mendenhall syndromes, severe forms of hyperinsulinemic insulin resistance for which no therapy is currently available. Systems have been developed that allow protein-protein interactions to be brought under the control of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dependovirus
• Share to Gene Transfer Techniques