Article

Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming

2026-04-27

Abstract excerpt

Sarcopenia, loss of muscle mass is a considerable health burden that demands immediate societal attention. Direct myogenic somatic cell reprogramming, a potential muscle regeneration method is constrained by an inability to control the signaling logic that governs cell fate. Here, we show that this barrier can be overcome using AI-designed receptor modulators. Screening de novo minibinders, we identify a synthetic...

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Literature Corpus work: 6a92cd61-b40a-54e0-b6e1-7b68f0dc36a7
DOI: 10.64898/2026.04.26.720818

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