Article

Structural Biophysics-Guided Computational Design of Semaglutide Analogues to Enhance GLP-1R Activation

2025-04-30

Abstract excerpt

CagriSema is a fixed-dose combination of cagrilintide (an amylin analogue) and semaglutide (a GLP-1 receptor agonist), and is currently an experimental obesity drug developed by Novo Nordisk. In March 2025, CagriSema underperformed expectations in a Phase III trial, achieving 15.7% weight loss instead of the anticipated 25%, raising concerns about its efficacy and clinical value. Given its chemical composition, th...

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Literature Corpus work: 0aef5258-2381-55b3-88ab-df8ac07d9987
DOI: 10.32388/fgtlkf

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