Article

A two-step <i>in vivo</i> CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target

2022-06-11

Abstract excerpt

<h4>SUMMARY</h4> Acute myeloid leukemia (AML) progression and relapse is fueled by self-renewing leukemic stem cells (LSCs) whose molecular determinants have been difficult to discern from normal hematopoietic stem cells (HSCs) or to uncover in screening approaches focused on general AML cell properties. We have identified a unique set of RNA binding proteins (RBPs) that are enriched in human AML LSCs but repress...

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Literature Corpus work: 56f2ab6c-0793-5513-afac-06e9aeaf417a
DOI: 10.1101/2022.06.11.494613

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