Article

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML

2020-12-28

Abstract excerpt

CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancers, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have been performed in vitro, evaluating the physiological relevance of these targets is critical. We have established a CRISPR screening approach using orthotopic xenograft m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: deef5cb9-2280-52af-8e8f-dce5b89fcc70
DOI: 10.1101/2020.12.28.424340

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AMLDOI 10.1101/2020.12.28.424340Read

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid LeukemiaSemantic proximity Read

Identification of novel genetic vulnerabilities and therapeutic targets in acute myeloid leukaemia using CRISPR dropout screensSemantic proximity Read

In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic TargetSemantic proximity Read

CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples.Semantic proximity Read

Functional Dependency Analysis Identifies Potential Druggable Targets in Acute Myeloid LeukemiaSemantic proximity Read

Synergistic effect of BCL2 and FLT3 co-inhibition in acute myeloid leukemiaSemantic proximity Read

ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid LeukemiaSemantic proximity Read

A two-step <i>in vivo</i> CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic targetSemantic proximity Read

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependenciesSemantic proximity Read

Targeting Mitochondrial Calcium Homeostasis via novel S100A9 Inhibitor B2 as a Promising Agent Against AMLSemantic proximity Read

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read

<i>In vivo</i> genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemiaSemantic proximity Read