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Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

16 Mar 2020

Abstract excerpt

Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells. Translocations involving the Mll1 (Kmt2a) gene generate powerful oncogenic fusion proteins, predominantly affecting infant and paediatric AML and ALL patients. The early stages of leukaemogenic...

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PMID: 32179751
DOI: 10.1038/s41467-020-15220-0

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