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Article

Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.

Scientific reports - 23 Jun 2021

Jaiswal Amit Kumar, Truong Hellen, Tran Tiffany M, Lin Tasha L, Casero David, Alberti Michael O, Rao Dinesh S

Abstract excerpt

Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute lymphoblastic leukemia (B-ALL) with MLL translocations, which carry a poor prognosis. Here, we sought to functionally characterize these dysregulated RBP genes by performing a...

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Share to Gene Expression Regulation, Leukemic
Share to Myeloid-Lymphoid Leukemia Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to RNA, Neoplasm

Share to RNA Processing, Post-Transcriptional

Share to Tumor Stem Cell Assay

Share to Vesicular Transport Proteins

Source

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Identifiers

PMID: 34162911
DOI: 10.1038/s41598-021-92448-w
PMCID: PMC8222245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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