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Article

Restoration of insulin receptor improves diabetic phenotype in T2DM mice

7 Aug 2019

Abstract excerpt

Type 2 diabetes mellitus (T2DM), also known as adult-onset diabetes, is characterized by ineffective insulin action due to insulin resistance in key metabolic tissues. Insulin receptor (IR) plays an important role in insulin signal transduction, defect of which has been considered the fundamental cause of T2DM. IR content reduction in diabetes is one key contributor to the defective insulin signaling and diabetes...

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PMID: 31391336
DOI: 10.1172/jci.insight.124945

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