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Article

Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice.

Endocrine journal - 1 Jan 2015

Sasaki Tsutomu, Kuroko Mitsutaka, Sekine Sawako, Matsui Sho, Kikuchi Osamu, Susanti Vina Yanti, Kobayashi Masaki, Tanaka Yoshinori, Yuasa Tomoyuki, Kitamura Tadahiro

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is one of the major health concern among the world. Several treatment options for T2DM are in clinical use, including injecting insulin, promoting insulin secretion by insulin secretagogues, and improving insulin sensitivity by insulin sensitizers. However, increasing the amount of insulin receptor in insulin-target tissues has not been explored. In order to test the efficacy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor Binding Protein 3

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Share to Receptor, Insulin

Source

Identifiers

PMID: 26096452
DOI: 10.1507/endocrj.EJ15-0255

Genes

INSR
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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