Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19

7 Feb 2022

Abstract excerpt

New emerging severe acute respiratory syndrome 2 (SARS-CoV-2) has caused a worldwide pandemic. Several animal models of coronavirus disease 2019 (COVID-19) have been developed and applied to antiviral research. In this study, two lethal mouse-adapted SARS-CoV-2 variants (BMA8 and C57MA14) with different virulence were generated from different hosts, which are characterized by high viral replication titers in the...

Topics

Join the communities discussing this publication.

COVID-19 Clinical Research Studies
Long-Term Effects of COVID-19
SARS-CoV-2 and COVID-19 Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35197985
DOI: 10.3389/fimmu.2022.821664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19PMID 35197985Read ↗

A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infectionSemantic proximity Read ↗

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challengeSemantic proximity Read ↗

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2Semantic proximity Read ↗

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2Semantic proximity Read ↗

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing miceSemantic proximity Read ↗

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory miceSemantic proximity Read ↗

Animal models for COVID-19: advances, gaps and perspectivesSemantic proximity Read ↗

Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 MiceSemantic proximity Read ↗

B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strainsSemantic proximity Read ↗

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human DiseaseSemantic proximity Read ↗

The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanSemantic proximity Read ↗

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.