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Humanization of the <i>rpb9</i> locus in fission yeast reveals conserved and divergent roles of <i>rpb9</i> and human <i>POLR2I</i>

2026-04-04

Abstract excerpt

<h4>Background/Objectives</h4> RNA polymerase II is a multifunctional complex that is critical for gene regulation and environmental responses. Its POLR2I subunit in human is associated with various pathologies, including cancer chemoresistance. However, much of our understanding of how POLR2I could function indirectly derives from studies of its homologs in yeasts called Rpb9. Here, we endogenously humanized the...

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Literature Corpus work
56e109e4-0a9d-5cdc-a61e-96186a90d56f
DOI
10.64898/2026.04.02.716003
Open publication

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Humanization of the <i>rpb9</i> locus in fission yeast reveals conserved and divergent roles of <i>rpb9</i> and human <i>POLR2I</i>DOI 10.64898/2026.04.02.716003
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