Article
RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo.
The Journal of biological chemistry - 10 Nov 2000
Hemming S A, Jansma D B, Macgregor P F, Goryachev A, Friesen J D, Edwards A M
Abstract excerpt
RNA polymerase II lacking the Rpb9 subunit uses alternate transcription initiation sites in vitro and in vivo and is unable to respond to the transcription elongation factor TFIIS in vitro. Here, we show that RPB9 has a synthetic phenotype with the TFIIS gene. Disruption of RPB9 in yeast also resulted in sensitivity to 6-azauracil, which is a phenotype linked to defects in transcription elongation. Expression of...
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