Article

Expression of the cancer-associated <i>DNA polymerase ε P286R</i> in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

2021-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations in the proofreading domain of the replicative DNA polymerase ε ( POLE -exonuclease domain mutations, POLE -EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associated cancers typically display hypermutation, microsatellite stability and a unique mutational signature, with a predominance of C > A transversions in the co...

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Literature Corpus work: d6829332-d1f4-5efd-897b-aff25c7f2e39
DOI: 10.1101/2021.04.06.438567

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