Article

An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens

2024-01-23

Abstract excerpt

The increased incidence of antibiotic resistance and declining discovery of new antibiotics have created a global health crisis, especially for the treatment of infections caused by Gram-negative bacteria. Here, we identify and characterize a molecule, NM102, that displays antimicrobial activity exclusively in the context of infection. NM102 inhibits the activity of the non-essential Mutation Frequency Decline (Mf...

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Identifiers and source

Literature Corpus work: 56d575d4-faff-525c-8b19-3cb10354620e
DOI: 10.1101/2024.01.22.576688

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