Article

High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications

2021-09-26

Abstract excerpt

Antibiotic tolerance is an understudied potential contributor to antibiotic treatment failure and the emergence of multidrug-resistant bacteria. The molecular mechanisms governing tolerance remain poorly understood. A prominent type of β-lactam tolerance relies on the formation of cell wall-deficient spheroplasts, which maintain structural integrity via their outer membrane (OM), an asymmetric lipid bilayer consis...

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Literature Corpus work: 929fad19-234a-5891-af34-d550c5dc6dbd
DOI: 10.1101/2021.09.25.461800

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