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Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in <i>Burkholderia pseudomallei</i>

2017-10-20

Abstract excerpt

Burkholderia pseudomallei , the causative agent of the high-mortality disease melioidosis, is a Gram-negative bacterium that is naturally resistant to many antibiotics. There is no vaccine for melioidosis, and effective eradication is reliant on biphasic and prolonged antibiotic administration. The carbapenem drug, meropenem, is the current gold-standard option for treating severe melioidosis. Intrinsic B. pseudo...

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Literature Corpus work
c820bbce-b22b-5145-975e-c6d02e9bf4c5
DOI
10.1101/205070
Open publication

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