Article

A preclinical resistance framework discovers the virulence risks of antibiotics in development

2026-07-21

Abstract excerpt

Several new antibiotics target multidrug-resistant pathogens, yet resistance is still evaluated mainly by drug-susceptibility, leaving consequences for bacterial pathogenicity poorly understood. Here, we develop a framework integrating resistance evolution, genomic surveillance and host–pathogen phenotyping to classify antibiotics by resistance potential and pathogenic consequences. Applying this framework to Kle...

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Literature Corpus work: 0fe84e9d-14ec-5eae-abef-5a93d1c13c23
DOI: 10.64898/2026.07.20.739514

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