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Engineering kidney developmental trajectory using culture boundary conditions

2024-12-16

Abstract excerpt

Kidney explant cultures are traditionally carried out at air-liquid interfaces, which disrupts 3D tissue structure and limits interpretation of developmental data. To overcome this limitation, we developed a 3D culture technique using hydrogel embedding to capture morphogenesis in real time. We show that 3D culture better approximates in vivo -like niche spacing and dynamic tubule tip rearrangement, as well as i...

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Identifiers and source

Literature Corpus work
d28eb24a-f59c-563a-a990-fb8d32df292a
DOI
10.1101/2024.12.10.627798
Open publication

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Engineering kidney developmental trajectory using culture boundary conditionsDOI 10.1101/2024.12.10.627798
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