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Article

Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism.

Cells - 3 Dec 2019

Melica Maria Elena, La Regina Gilda, Parri Matteo, Peired Anna Julie, Romagnani Paola, Lasagni Laura

Abstract excerpt

Stem cell (SC)-based tissue engineering and regenerative medicine (RM) approaches may provide alternative therapeutic strategies for the rising number of patients suffering from chronic kidney disease. Embryonic SCs and inducible pluripotent SCs are the most frequently used cell types, but autologous patient-derived renal SCs, such as human CD133+CD24+ renal progenitor cells (RPCs), represent a preferable option....

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Identifiers

PMID: 31816967
DOI: 10.3390/cells8121561
PMCID: PMC6953094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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