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Article

Temporal landscape of mitochondrial proteostasis governed by the UPR mt

22 Sept 2023

Abstract excerpt

Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR mt ) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPR mt remodels and restores damaged mitochondrial proteomes. Here, we have developed a functional proteomics framework, termed MitoPQ...

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PMID: 37738349
DOI: 10.1126/sciadv.adh8228

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