Article

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz

2022-07-11

Abstract excerpt

Cells integrate mechanical cues to direct fate specification to maintain tissue function and homeostasis. While disruption of these cues is known to lead to aberrant cell behavior and chronic diseases, such as tendinopathies, the underlying mechanisms by which mechanical signals maintain cell function is not well understood. Here, we show using a novel model of tendon de-tensioning that loss of tensile cues in vi...

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Identifiers and source

Literature Corpus work: 56b79ad7-e197-5287-ae3b-16dfdf567375
DOI: 10.1101/2022.07.11.499650

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