Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic regulation and mechanobiological adaptation in tenocytes during maturation

1 Jun 2025

Abstract excerpt

Tendons are essential for musculoskeletal function, facilitating movement by transmitting forces from muscles to bones. However, aging alters the tendon microenvironment, disrupting the delicate interactions between tenocytes and the extracellular matrix (ECM), contributing to tissue degeneration. While prior studies have characterized the mechanical and structural changes in tendons during maturation, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital limb and hand anomalies
Share to Sports injuries and prevention
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40584816
DOI: 10.1063/5.0271050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic regulation and mechanobiological adaptation in tenocytes during maturationPMID 40584816Read ↗

Remodeling of cytoskeleton, chromatin, and gene expression during mechanical rejuvenation of aged human dermal fibroblastsSemantic proximity Read ↗

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read ↗

New Insights into Neuromuscular Contracture Reveals Myotendinous-SMAD4 Signaling Underlies Contracture FormationSemantic proximity Read ↗

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling PathwaySemantic proximity Read ↗

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read ↗

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and TazSemantic proximity Read ↗

Intra-Nuclear Tensile Strain Mediates Reorganization of Epigenetically Marked Chromatin During Cardiac Development and DiseaseSemantic proximity Read ↗

Stress deprivation of tendon explants or Tpm3.1 inhibition in tendon cells reduces F-actin to promote a tendinosis-like phenotype.Semantic proximity Read ↗

Destabilization of F-actin by Mechanical Stress Deprivation or Tpm3.1 Inhibition Promotes a Pathological Phenotype in Tendon CellsSemantic proximity Read ↗

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by AgingSemantic proximity Read ↗

Sex differences in tendon structure and functionSemantic proximity Read ↗

Achilles Tendons Display Region-Specific Transcriptomic Signatures Associated With Distinct Mechanical PropertiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.