Article

Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I expression and organization

2017-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro , while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Os...

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Literature Corpus work: 301eac6e-ae18-5b76-a22b-08b7bacfaf51
DOI: 10.1101/143982

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