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Mechanosensitive transcriptional coactivators MRTF‐A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

22 Oct 2019

Abstract excerpt

Cells of the adult nucleus pulposus (NP) are critically important in maintaining overall disc health and function. NP cells reside in a soft, gelatinous matrix that dehydrates and becomes increasingly fibrotic with age. Such changes result in physical cues of matrix stiffness that may be potent regulators of NP cell phenotype and may contribute to a transition toward a senescent and fibroblastic NP cell with a...

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PMID: 31638828
DOI: 10.1096/fj.201802725rrr

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