Article

STAG2 cohesin is essential for heart morphogenesis

2019-09-30

Abstract excerpt

The distinct functions of cohesin complexes carrying STAG1 or STAG2 need to be unraveled. STAG2 is commonly mutated in cancer and germline mutations have been identified in cohesinopathy patients. To better understand the underlying pathogenic mechanisms, we here report the consequence of Stag2 ablation in mice. STAG2 is largely dispensable in adults and its tissue-wide inactivation does not lead to tumors but r...

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Literature Corpus work: 0e5b1398-e314-528e-9271-cfdc74d40190
DOI: 10.1101/788158

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