Article
Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci
2024-10-24
Abstract excerpt
Genetics is the second strongest risk factor for Alzheimer's disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. To better understand nonadditive impact of single-nucleotide polymorphisms (SNPs) on AD risk, we examined individual, joint, and interacting (SNPxSNP) effects o...
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Identifiers and source
- Literature Corpus work
- 5674505a-a83d-5930-ab4d-a974a887dba7
- DOI
- 10.1101/2024.10.24.24316008